Cholesterol Metabolism and Diabetes

Cholesterol metabolism is altered in the diabetes. Absorption is decreased in diabetes and cholesterol biosynthesis is increased. In type-2 diabetes in obesity and also in conditions such as cortisol excess (Cushing’s Syndrome), raised insulin levels are found frequently. Lack of insulin can lower the level of "good" cholesterol (high density lipoprotein). When insulin is given and then well controlled, HDL numbers will typically go back to normal. Cholesterol problems in people who have type-1 diabetes are related to the lack of insulin.

  • Insulin resistance
  • Cholesterol absorption
  • Cholesterol synthesis
  • Enterohepatic circulation
  • Sterols and diabetes
  • The succinate hypothesis

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